Approximately 54 results found in the Worldwide database for:
hirudin in the title(Results are sorted by date of upload in database)

1 MODIFIED HIRUDIN PROTEINS AND T-CELL EPITOPES IN HIRUDIN in my patents list
Inventor: BAKER MATTHEW (GB); WATKINS JOHN (GB) Applicant: MERCK PATENT GMBH (DE); BAKER MATTHEW (GB); (+1)
EC: C07K14/815 IPC: C07K14/815
Publication info: WO2004113386 - 2004-12-29

2 Inventor: HABERMANN PAUL (DE); ERTL JOHANN (DE) Applicant: AVENTIS PHARMA GMBH (DE)
EC: C07K14/62; C07K14/815; (+2) IPC: C12N15/62; C12N15/70; (+5)
Publication info: EP1364029 - 2003-11-26

3 USE OF MOLECULAR WEIGHT-AMPLIFIED HIRUDIN AS AN ANTICOAGULANT IN EXTRACORPOREAL RENAL REPLACEMENT THERAPY in my patents list
Inventor: NOWAK GOETZ (DE); BUCHA ELKE (DE) Applicant: MAX PLANCK GESELLSCHAFT (DE); NOWAK GOETZ (DE); (+1)
EC: A61K38/58 IPC: A61K31/00
Publication info: WO0061121 - 2000-10-19

4 A complex buffer system for the CZE analysis of hirudin in my patents list
Inventor: DOENGES REINER (DE); BRAZEL DIETER DR (DE); (+1) Applicant: AVENTIS PHARMA GMBH (DE)
EC: G01N27/447B5; G01N33/48; (+1) IPC: G01N33/68
Publication info: EP1026505 - 2000-08-09

5 METHOD FOR DETERMINING ADMINISTRATION PLAN CONCERNING HIRUDIN OF THROMBIN INHIBITOR FOR ORAL ADMINISTRATION in my patents list
Inventor: NOERTERSHEUSER PETER DR; KREIS SIEGFRIED Applicant: KNOLL AG
EC: IPC: A61K38/00; A61K31/00; (+3)
Publication info: JP11279073 - 1999-10-12

6 HIRUDIN-CONTAINING MEDICINAL COMPOSITION AND ITS PRODUCTION in my patents list
Inventor: DEIITAA BURAATSUERU Applicant: BEHRINGWERKE AG
EC: IPC: A61K38/55; A61K31/70; (+3)
Publication info: JP9227407 - 1997-09-02

7 PROCESS FOR FOLDING OF PROTEINS LIKE RECOMBINANT HIRUDIN OR EPIDERMAL GROWTH FACTOR in my patents list
Inventor: CHANG JUI YOA (CH) Applicant: CIBA GEIGY AG (CH); CHANG JUI YOA (CH)
EC: C07K1/113D; C07K14/485; (+1) IPC: C07K1/113; C07K14/485; (+1)
Publication info: WO9603425 - 1996-02-08

8 PROCESS FOR FOLDING OF PROTEINS LIKE RECOMBINANT HIRUDIN OR EPIDERMAL GROWTH FACTOR in my patents list
Inventor: CHANG JUI YOA (CH) Applicant: CIBA GEIGY AG (CH)
EC: IPC: C07K1/113; C07K14/485; (+1)
Publication info: EP0804461 - 1997-11-05

9 HIRUDIN DERIVATIVE in my patents list
Inventor: CRAUSE PETER (DE); TRIPIER DOMINIQUE (DE); (+1) Applicant: HOECHST AG (DE)
EC: C07K14/815 IPC: C07K14/815; C12N15/15; (+2)
Publication info: HU9500596 - 1995-10-30

10 Use of polyethylene glycol-hirudin to treat unstable angina pectoris in my patents list
Inventor: KIRCHENGAST MICHAEL DR (DE); RUEBSAMEN KLAUS DR (DE) Applicant: KNOLL AG (DE)
EC: A61K38/58 IPC: A61K38/58
Publication info: DE19513855 - 1996-10-17

11 HIRUDIN DERIVATIVES AND A PROCESS FOR THEIR PREPARATION in my patents list
Inventor: OBERMEIER RAINER (DE); LUDWIG JUERGEN (DE); (+2) Applicant: HOECHST AG (DE)
EC: IPC: C12P21/06; A61K38/58; (+1)
Publication info: CA2142173 - 1995-08-11

12 Topical compsns. contg. hirudin or heparin in my patents list
Inventor: SCHMIDT ERNST-GUENTHER DIPL PH (DE) Applicant: SCHMIDT ERNST GUENTHER DIPL PH (DE)
EC: A61K31/727; A61K38/58 IPC: A61K38/58; A61K31/725
Publication info: DE4445317 - 1996-06-20

13 Conjugates of hirudin with lipophilic cpds in my patents list
Inventor: SUBKOWSKI THOMAS DR (DE); SCHWEDEN JUERGEN DR (DE); (+2) Applicant: BASF AG (DE)
EC: A61K47/48H4; A61K47/48H4H IPC: A61K38/58
Publication info: DE4437502 - 1995-06-08

14 ANALOGS OF HIRUDIN in my patents list
Inventor: KU CECILIA S L; JOHNSON RICHARD; (+1) Applicant: BAXTER INT (US)
EC: C07K14/815 IPC: C07K14/00
Publication info: WO9507295 - 1995-03-16

15 Hirudin mutant, production thereof, anticoagulant, secretory vector, and production of product from said microorganism in my patents list
Inventor: Applicant: NIPPON MINING CO LTD
EC: C07K14/815; C12N9/16; (+1) IPC: C12N15/71; C12N15/70; (+3)
Publication info: AU5470194 - 1994-03-24

16 PRODUCTION OF SULFATE DERIVATIVE OF HIRUDIN ANALOG OR ITS SALT in my patents list
Inventor: MITSUMOTO TSUTOMU; MURAMATSU SATORU; (+1) Applicant: JAPAN ENERGY CORP; FUJI YAKUHIN KOGYO KK
EC: IPC: C07K14/815; A61K38/55; (+2)
Publication info: JP7138298 - 1995-05-30

17 ANTIDOTE FOR HIRUDIN AND SYNTHETIC THROMBIN INHIBITORS in my patents list
Inventor: NOWAK GOETZ (DE); BUCHA ELKE (DE) Applicant: MAX PLANCK GESELLSCHAFT (DE)
EC: C12N9/64E4; C12N9/74 IPC: A61K37/475; A61K37/54; (+2)
Publication info: WO9315757 - 1993-08-19

18 ANALOGS OF HIRUDIN in my patents list
Inventor: KU CECILIA S L (US); JOHNSON RICHARD (US); (+1) Applicant: BAXTER INT (US)
EC: A61K47/48R; C07K14/815 IPC: C07K7/10; C07K17/00
Publication info: WO9304082 - 1993-03-04

19 HIRUDIN ANALOGUES AND PROCESS FOR THEIR PREPARATION in my patents list
Inventor: SCACHERI EMANUELA; RONCUCCI ROMEO; (+3) Applicant: MINI RICERCA SCIENT TECNOLOG (IT)
EC: C07K14/815 IPC: A61K37/02; C07K7/10
Publication info: GB2257974 - 1993-01-27

20 ANTI-HIRUDIN POLYCLONAL ANTIBODIES AND THEIR USE FOR THEIDENTIFICATION, IMMUNOPURIFICATION AND QUANTITATIVEDETERMINATION OF HIRUDIN in my patents list
Inventor: MOLINARI ANTONIO; GERNA MARCO; (+3) Applicant: ERBA CARLO SPA (IT)
EC: C07K14/815; C07K16/38 IPC: C07K15/00; G01N33/00
Publication info: IE922081 - 1992-12-30

21 Hirudin analogue, method for the production thereof and anticoagulant containing it, and secretion vector, microorganisms transformed with said vector, and method for the production of products from said microorganisms in my patents list
Inventor: MATSUDA HITOSHI (JP); MISAWA SATOROU (JP); (+2) Applicant: NIPPON MINING CO (JP)
EC: IPC: C12P21/00; C12N15/00
Publication info: PT100299 - 1993-09-30

22 HIRUDIN ANALOGUE OR SALT THEREOF, PRODUCTION THEREOF, AND ANTICOAGULANT CONTAINING THE SAME AS ACTIVE INGREDIENT in my patents list
Inventor: MURAMATSU RYO (JP); SUKESADA AKIKO (JP); (+4) Applicant: NIPPON MINING CO (JP); FUJI YAKUHIN KOGYO KK (JP)
EC: C07K14/815 IPC: A61K37/02; A61K37/64; (+2)
Publication info: WO9215610 - 1992-09-17

23 USE OF HIRUDIN, ITS MUTEINS AND THE PEG DERIVATIVES THEREOF FOR THE COMBINATION TREATMENT OF TUMORS in my patents list
Inventor: KLUGE MICHAEL (DE) Applicant: KNOLL AG (DE)
EC: A61K38/58 IPC: A61K38/58
Publication info: CA2098707 - 1992-06-22

24 SOLUBLE HIRUDIN CONJUGATES in my patents list
Inventor: ITO RALPH K (US); LOGERFO FRANK W (US) Applicant: NEW ENGLAND DEACONESS HOSPITAL (US)
EC: A61K38/58; A61K47/48R2H IPC: A61F2/00; A61K31/00; (+1)
Publication info: WO9205748 - 1992-04-16

25 ANALOGS OF HIRUDIN in my patents list
Inventor: WINANT RICHARD C (US); LAZAR JEROME B (US); (+1) Applicant: STANFORD RES INST INT (US)
EC: C07K14/815 IPC: A61K37/64; C07K7/10; (+3)
Publication info: WO9201712 - 1992-02-06

26 ORAL PHARMACEUTICAL COMPOSITIONS CONTAINING HIRUDIN in my patents list
Inventor: Applicant: IKETON FARMACEUTICI SRL (IT)
EC: A61K9/127; A61K38/58 IPC: A61K37/02
Publication info: IE912566 - 1992-01-29

27 Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin in my patents list
Inventor: KRSTENANSKY JOHN L (US); MAO SIMON J T (US) Applicant: MERRELL DOW PHARMA (US)
EC: C07K14/815 IPC: A61K37/02; C07K7/00
Publication info: EP0443429 - 1991-08-28

28 METHOD OF PREPARATION OF HIRUDIN in my patents list
Inventor: KOERWER WOLFGANG (DE) Applicant: BASF AG (DE)
EC: C07K14/31; C07K14/815 IPC: C07K7/10; C12N15/15; (+3)
Publication info: WO9109946 - 1991-07-11

29 Hirudin conjugates with polyoxyethylene in my patents list
Inventor: GODDARD PETER; BROWN LYNDON NIGEL; (+1) Applicant: CIBA GEIGY AG (CH)
EC: A61K38/58; A61K47/48H4P IPC: A61K37/64; C07K17/08
Publication info: GB2247239 - 1992-02-26

30 EXPRESSION VECTOR FOR HIRUDIN, HIRUDIN FUSION PROTEIN,TRANSFORMED MICROORGANISM AND METHOD FOR PRODUCTION OFHIRUDIN in my patents list
Inventor: Applicant: JAPAN ENERGY CORP (JP)
EC: C07K14/815 IPC: C12N1/21; C12N15/15; (+3)
Publication info: IE902877 - 1991-02-27

31 HIRUDIN-MANIFESTNG VECTOR, HIRUDIN-FUSED PROTEIN, TRANSFORMANT MICROORGANISM AND PRODUCTION OF HIRUDIN in my patents list
Inventor: MISAWA SATORU; MATSUDA HITOSHI; (+1) Applicant: NIPPON MINING CO
EC: IPC: A61K37/64; C07K15/12; (+3)
Publication info: JP3164184 - 1991-07-16

32 HIRUDIN PEPTIDE DERIVATIVES in my patents list
Inventor: MARAGANORE JOHN M (US) Applicant: BIOGEN INC (US)
EC: A61K38/00; A61K38/16B1; (+4) IPC: A61K37/64; C07K7/08
Publication info: WO9101328 - 1991-02-07

33 POLYPEPTIDE HAVING THROMBIN INHIBITING ACTIVITY AND PROCESS FOR THE MANUFACTURE THEREOF in my patents list
Inventor: FURUTANI YOSHIO (JP); HONJO MASARU (JP); (+5) Applicant: MITSUI TOATSU CHEMICALS (JP)
EC: C07K14/815; C12N9/54 IPC: C07K7/10; C12N1/21; (+3)
Publication info: CA2018211 - 1990-12-09

34 New hirudin-poly:alkylene glycol conjugate(s) - used as anticoagulants for treatment and prophylaxis of myocardial infarct, arterial occlusion, venous thrombosis and pulmonary embolism in my patents list
Inventor: KURFUERST MANFRED DR (DE); RUEBSAMEN KLAUS DR (DE); (+1) Applicant: BASF AG (DE)
EC: A61K47/48H4P; C07K14/815 IPC: A61K37/02; C07K15/04
Publication info: DE4014260 - 1991-06-06

35 New anticoagulant hirudin-polyvinyl lactam conjugates - for treating e.g. myocardial infarction, peripheral arterial occlusion disorders, deep venous thrombosis and pulmonary embolism in my patents list
Inventor: KURFUERST MANFRED DR (DE); SCHMIED BERNHARD DR (DE); (+2) Applicant: BASF AG (DE)
EC: C07K14/815 IPC: A61K37/02; C07K7/10
Publication info: DE4011375 - 1991-10-10

36 Hirudin fragments in my patents list
Inventor: CHANG JUI YOA Applicant: CIBA GEIGY AG (CH); UCP GEN PHARMA AG (CH)
EC: C07K14/815 IPC: C07K7/10; C12N15/15
Publication info: GB2242681 - 1991-10-09

37 Improved yeast strains for the production of mature heterologous proteins, in particular of hirudin in my patents list
Inventor: LEMOINE YVES (FR); NGUYEN MARTINE (FR); (+1) Applicant: TRANSGENE SA (FR)
EC: C07K14/815; C12N9/60; (+1) IPC: C12N1/18; C12N15/15; (+2)
Publication info: EP0396436 - 1990-11-07

38 Hirudin-coated biocompatible substance in my patents list
Inventor: ITO RALPH K; LOGERFO FRANK W Applicant: NEW ENGLAND DEACONESS HOSPITAL (US)
EC: A61L33/00H2F; A61L33/12R IPC: A61L33/00
Publication info: EP0357242 - 1990-03-07

39 HIRUDIN PEPTIDES in my patents list
Inventor: MARAGANORE JOHN M (US) Applicant: BIOGEN INC (US)
EC: C07K14/815 IPC: C07K7/06; C07K7/08; (+3)
Publication info: WO9003391 - 1990-04-05

40 Hirudin peptides in my patents list
Inventor: MARAGANORE JOHN M Applicant: BIOGEN INC (US)
EC: C07K14/815 IPC: A61K37/00; C07K7/00; (+1)
Publication info: EP0333356 - 1989-09-20

41 Hirudin peptides for inhibiting platelet aggregation in my patents list
Inventor: JAKUBOWSKI JOSEPH; MARAGANORE JOHN M Applicant: BIOGEN INC (US); UNIV BOSTON (US)
EC: C07K14/815 IPC: A61K37/02
Publication info: EP0372670 - 1990-06-13

42 Hirudin derivative in my patents list
Inventor: CRAUSE PETER DR (DE); HABERMANN PAUL DR (DE); (+1) Applicant: HOECHST AG (DE)
EC: C07K14/815 IPC: A61K37/02; C07H21/04; (+4)
Publication info: DE3900626 - 1989-07-27

43 Method for preparing a hirudin in my patents list
Inventor: FURUTANI YOSHIO; HONJO MASARU; (+4) Applicant: AGENCY IND SCIENCE TECHN (JP)
EC: C07K14/815; C12N9/54 IPC: C12N1/20; C12N15/00; (+1)
Publication info: EP0352387 - 1990-01-31

44 Recombinant DNA expression vector which encodes hirudin, cultures of infected or transformant mammalian cells, process for preparing hirudin and protein obtained in my patents list
Inventor: SKERN TIMOTHY; COURTNEY MICHAEL Applicant: TRANSGENE SA (FR)
EC: C07K14/815; C12N15/863V IPC: C07K7/10; A61K37/02; (+2)
Publication info: FR2611723 - 1988-09-09

45 THROMBIN INHIBITOR HIRUDIN ACTIVITY in my patents list
Inventor: MEYHACK BERND; MARKI WALTER; (+1) Applicant: CIBA GEIGY AG; CHRISTENSEN PLANTORGAN WERK
EC: C07K14/815; C12N9/16; (+4) IPC: C12N15/00; C12N1/16; (+5)
Publication info: AU6650486 - 1987-06-18

46 Improved vectors for expressing a variant of hirudin in yeasts, process and product obtained in my patents list
Inventor: LABAT NATHALIE; LOISON GERARD; (+2) Applicant: TRANSGENE SA (FR)
EC: C07K14/815; C12N15/62A; (+1) IPC: C12N15/00; C12N1/16; (+6)
Publication info: FR2607516 - 1988-06-03

47 Improved vectors for the expression of hirudin in yeasts, process and product obtained in my patents list
Inventor: LOISON GERARD (FR); LEMOINE YVES (FR) Applicant: TRANSGENE SA (FR)
EC: C07K14/39; C07K14/395; (+2) IPC: C12N15/00; A61K37/02; (+5)
Publication info: FR2601383 - 1988-01-15

48 DNA SEQUENCES ENCODING HIRUDIN-LIKE PROTEIN AND PROCESS FOR PRODUCING SUCH PROTEINS in my patents list
Inventor: FORTKAMP ELKE; RIEGER MICHAEL; (+2) Applicant: GEN BIO TEC GES GENTECH; BIOTECHNOLOG FORSCHUNG GMBH; (+1)
EC: C07K14/815 IPC: A61K37/02; C12P21/02; (+3)
Publication info: HU46061 - 1988-09-28

49 A genetic engineering process for the preparation of hirudins, and means for carrying out this process in my patents list
Inventor: Applicant: HOECHST AG (DE)
EC: C07H21/00C4; C07K14/815; (+1) IPC: C12N15/62; C12N1/20; (+2)
Publication info: IE58485 - 1986-02-10

50 Expression vectors for hirudin, transformed cells and process for the preparation of hirudin in my patents list
Inventor: TOLSTOSHEV PAUL (FR); HARVEY RICHARD (FR); (+2) Applicant: TRANSGENE SA (FR)
EC: C07K14/815; C12N15/70 IPC: A61K35/16; A61K37/64; (+7)
Publication info: EP0158564 - 1985-10-16

51 Vector for expressing hirudin, process for preparing it by culturing transformed cells and the hirudin obtained in my patents list
Inventor: TOLSTOSHEV PAUL; HARVEY RICHARD; (+2) Applicant: TRANSGENE SA (FR)
EC: C12N15/00 IPC: C12N15/00; A61K37/02; (+1)
Publication info: FR2569420 - 1986-02-28

52 Vectors for expressing hirudin, transformed cells and process for preparing hirudin in my patents list
Inventor: TOLSTOSHEV PAUL; HARVEY RICHARD; (+2) Applicant: TRANSGENE SA (FR)
EC: C12N15/00 IPC: C12N15/00; A61K37/02; (+1)
Publication info: FR2562088 - 1985-10-04

53 Process for the production of purified hirudin in my patents list
Inventor: MARKWARDT FRITZ; SCHAFER GERHARD; (+2) Applicant: DRESDEN ARZNEIMITTEL
EC: IPC:
Publication info: GB1032323 - 1966-06-08

54 Process for the production of hirudin in my patents list
Inventor: MARKWARDT FRITZ; WALSMANN PETER; (+2) Applicant: DRESDEN ARZNEIMITTEL
EC: IPC:
Publication info: GB1031840 - 1966-06-02

美国专利目录:

PAT. NO. Title
1 6,719,975 Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
2 6,514,730 Secretion of hirudin derivatives
3 6,060,451 Thrombin inhibitors based on the amino acid sequence of hirudin
4 6,028,170 Analogs of hirudin
5 5,972,648 Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
6 5,919,895 Secretion of hirudin derivatives
7 5,919,762 Conjugates of hirudin and lipophilic compounds
8 5,902,735 Functional DNA block and plasmid coding for hirudin, transformed yeast, method for hirudin, hirudin obtained, and its pharmaceutical use
9 5,880,258 Anticoagulant hirudin variants and methods for their production
10 5,879,926 Yeast strains for the production of mature heterologous proteins, especially hirudin
11 5,866,399 Process for inactivating carboxypeptidase Y in hirudin-containing culture broths
12 5,837,808 Analogs of hirudin
13 5,824,505 Vectors, transformed cells and process for the preparation of hirudin
14 5,821,079 Vectors for the expression and secretion of hirudin by transformed yeasts
15 5,817,309 Antidote for hirudin and synthetic thrombin inhibitors and method of use
16 5,767,235 Anticoagulant hirudin variants and methods for their production
17 5,705,355 Hirudin, pharmaceutical compositions comprising it and their use
18 5,698,104 Purification process for hirudin using affinity chromatography
19 5,686,564 Peptide derivatives corresponding to the carboxy terminal sequence of hirudin
20 5,674,838 Hirudin derivatives and a process for their preparation
21 5,663,141 Hirudin/polyalkylene glycol conjugates and hirudin muteins
22 5,650,301 Hirudin HV2 having a SN7LYS substitution, method of making, and method of use
23 5,624,822 Hirudin fusion proteins and preparation of hirudin
24 5,591,640 Functional DNA block and plasmid coding for hirudin, transformed yeast, method for preparing hirudin, hirudin obtained and its pharmaceutical use
25 5,574,012 Analogs of hirudin having anti-platelet activity
26 5,573,929 Secretion vector for hirudin or hirudin analog production
27 5,547,850 Process for determining hirudin and synthetic thrombin inhibitors
28 5,541,161 Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
29 5,538,946 Hirudin derivatives with delayed action
30 5,516,656 Production of a new hirudin analog and anticoagulant pharmaceutical composition containing the same
31 5,472,938 Pharmaceutical depot compositions containing hirudin
32 5,362,858 Polyethylene glycol-hirudin conjugates, process for preparing them and their use for the treatment of thromboses
33 5,304,310 Method for concentrating and purifying hirudin from leeches
34 5,296,352 Monoclonal antibodies directed against complexes formed by thrombin and hirudin
35 5,272,059 Monoclonal antibodies specific for hirudin
36 5,204,323 Heparin and hirudin antidotal compositions and methods
37 5,180,668 Hirudin derivative
38 5,167,960 Hirudin-coated biocompatible substance
39 5,164,304 Method and vectors for stabilizing hirudin and human laminin B.sub.1 expression
40 5,118,790 Analogs of hirudin
41 5,112,615 Soluble hirudin conjugates
42 5,095,092 Process for the isolation and purification of hirudin
43 5,087,613 Hirudin variants
44 4,767,742 Hirudin-PA and its derivatives, process for manufacturing these and the use of these substances

PUB. APP. NO. Title
1 20050095685 Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
2 20040228852 Use of increased molecular-weight hirudin as an anticoagulant in extracorporeal kidney replace therapy
3 20030176673 Nucleic acids, proteins, and processes thereof such as use of fusion proteins whose N-terminal part is a hirudin derivative for the production of recombinant proteins via secretion by yeasts
4 20020173620 Bifunctional fusion proteins formed from hirudin and TAP